By nominating so many bad apples, Trump has ensured his opponents have to fight on too many fronts and in the end all the bad apples could get in. It may be that there are only are few key ones and with so many fronts, they have a better chance to sneak in. But if there was a concerted effort to focus on only some of the most odious nominations then perhaps those could be defeated.
Of course, concerned people would have to agree on which were the worse and to focus all efforts at stopping them. Personally, I find them all reprehensible but the P-bodies are, perhaps, the worst of the worst: Pruitt and Pudzer.