I read an article this morning on the Motley Fool about how the solution to weeds becoming resistant to glyphosate is rotational herbicide application: one year you spray glyphosate, the next year 2,4-D. The real solution is to recognize that agrichemicals are a failed experiment and it's time to use science, technology, and mostly experience to wean agriculture off of a failed experiment that has not died a natural death because of just one fact: it makes corporations money.
GMOs have not led to higher yields, or more nutritional food or reduced hunger worldwide. There is no beneficial GMO trait that hasn't also been achieved through conventional cross-breeding techniques. In the U.S., the main sociological effect GMOs have had is to increase the size of farms and reduce the number of farmers. The main environmental effect has been to saturate the land and water with chemicals that do tremendous damage to organisms at the base of the life web--microbes and insects. Extinction level damage. As far as health effects, there are alarming correlations reported from all over the world with the use of glyphosate--liver and kidney disease, DNA mutations, allergies, intestinal diseases, autism.
The justification the GMO industry offers for their manufactured agrichemical dependence is that they are a necessary evil but, if you dig deep enough behind the industry spin, this is simply not true.