The biggest concern with the TPP was its sell out to corporations who gained the ability to sue nations for losses that would occur due to regulations that would prevent profitable operations. That aspect of the TPP should be considered unconstitutional by all nations involved.
Aside from that most important point, housing in the USA comes with car-dependency. Banks gladly finance the homes knowing they’ll finance automobile sales as well. This issue - car-mageddon - just like global trade, benefits fuel/oil industries whose leaders couldn’t care less about miserable traffic nor the specter of global warming disrupting ecosystems and weather patterns. Trump is leading the GOP’s final solution to, in their view, world over-population. The more dependent we become on global trade, the more vulnerable we become to any disruption to the transport of essential goods and commodities. When the oil companies decide to turn off the spigot, starvation and bloody battles for food and water will erupt worldwide with armament supplied by fattened corporate golf buddies.